# \#methyl-seq

**URL:** https://awg.osdr.space/tag/methyl-seq/291.md

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## [Updates to MethylSeq pipeline draft](https://awg.osdr.space/t/updates-to-methylseq-pipeline-draft/1880)

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**Author:** [@barbara.novak](https://awg.osdr.space/u/barbara.novak)\
**Replies:** 0\
**Last updated:** [February 15, 2025, 12:05am UTC](https://awg.osdr.space/t/updates-to-methylseq-pipeline-draft/1880 "2025-02-15T00:05:27Z")

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Hi AWG members, Upon processing the first 4 MethylSeq datasets, we decided to make a few updates to the recently approved Methyl-Seq pipeline. You can find the latest updates here. Please click on the link and let us know if you have any issues with the updates no later than Sunday, Feb 23rd. Updates include the following: Added a filtering and normalization step prior to differential methylation analysis. For studies in which the coverage is fairly similar across the samples, this step wil…