A new Microbes AWG paper Spaceflight alters host-gut microbiota interactions is out.
The study shows >40 microbiome species altered in mice from (RR6 - amplicon and WMS) during spaceflight, including rare but important (structural zeros) bacteria, and compares changes with colon and liver gene expression.
Only the one mission (RR6) but there’s also some fun interactive figures of the metagenomics here (interesting stats implications for Supplementary figure X. MAGs vs Contig Annotation) and some detailed RNAseq pathway pictures in the supplementary file for those interested in the detailed host genetics.
Cheers and congrats to the various members of the @MicrobesAWG who contributed to this research!!
13 Likes
Hearty Congratulations Nic <3 Nice and interesting work !
3 Likes
Woot! And I love @emmanuel.gonzalez’s live htmls/interactive images!
3 Likes
It really is a spectacular read, love all the figures, and that bonus interactive is CHEFS KISS.
Never had seen those Bion references before. Just really well written/structured, a good science story. Finished it about an hour ago, reading from alpha to omega.
Cheers to all the authors - and thanks to GeneLab for paying for the open access publishing! So glad it is listed in the Nature Portflio SOMA package collection! Space Omics and Medical Atlas (SOMA) across orbits
3 Likes
Congratulations all! I’m so looking forward to reading this today!
2 Likes
Great summary, Nick! Exciting to see this new Microbes AWG paper finally out and exploring such fascinating host-microbe interactions!
There was indeed a lot to unpack with the metagenomics, WGS, and host RNAseq data. Huge thanks to all the contributors from @MicrobesAWG for their hard work and dedication on this!
Thank you, @rtscott2001! I’m glad you enjoyed the paper, and your kind words mean a lot to the team!
Thanks @AstrobioMike , glad you liked the interactive images. Multiomics figures are always a challenge with so much to pack in!
Looking forward to more collaborations with the GeneLab AWG team in the future!
4 Likes
@nicholas.brereton @emmanuel.gonzalez coild you recap the history of this project? It’s a marvelous example of Open Science on several levels.
I do recall Jon Galazka initiating, but also @stefan_green playing a substantial role
Maybe it seriched from a methods validation to analysis? I’m unsure. Perhaps @AstrobioMike recalls as well. @Fathi ?
Thx - trying to spread kudos on this, but need more background
1 Like
Thanks Ryan – We’re not the best example of a slick team, largely because we (I) didn’t do a good job with communication on the project. The recent OSDR forums have been a real gift for this in enabling subgroups to focus down on a project (it’s much easier now). We were quite slow on this project but it worked out quite well in the end and it was great to work with the team.
I could outline some, mostly, technical points from the paper we’d like discussion on? Including some new methods which we’d prepared for fighting in review (but weren’t raised).
2 Likes
That’s good this forum immediately helps on communication, engagement, sub-groups, etc
Not a big deal on the other stuff. Just big super kudos on the perseverance and collaborative spirit to see the study through.
The fact that 3 “GeneLab for High School” students had their summer cohort research contribute to the study is just so so so cool
Cheers!
1 Like