This is a longstanding listserve of articles relevant to space biology, space health, etc
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SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at SPACELINE Current Awareness. Please send any correspondence or request to unsubscribe to Shawna Byrd, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.
In case you missed it : A Science Strategy for the Human Exploration of Mars is a newly published book published by the National Academies of Sciences, Engineering, and Medicine. For more information and how to access this book go to https://www.nationalacademies.org/publications/28594.
Papers deriving from NASA support:
1
Daniel Estrella L, Sveeggen TM, de la Guardia G, Cacho J, Stauch KL, Bagher P.
A systematic review of the cerebrovascular adaptations following exposure to spaceflight or ground-based analogs: Lessons from human and animal studies .
npj Microgravity. 2025 Dec 12. Review. Early access article.
https://pubmed.ncbi.nlm.nih.gov/41387730
Note: This article may be obtained online without charge.
Journal Impact Factor: 5.1
Funding: HL155618/HL/NHLBI NIH HHS/United States; 80NSSC19K0392/NASA/NASA/United States
2
Jones-Isaac K, Yeung CK, Bain J, Lidberg K, Yang J, Wang L, MacDonald J, Bammler T, Thummel KE, Corn M, Ruiz MV, Countryman S, Koenig P, Mann HH, Himmelfarb J, Kelly EJ.
Effect of calcium oxalate microcrystals on kidney proximal tubule epithelial cell gene expression in microgravity .
npj Microgravity. 2025 Dec 11. Early access article.
https://pubmed.ncbi.nlm.nih.gov/41381544
Note: From the article: “In the unique microgravity environment of the International Space Station National Laboratory (ISSNL), COM microcrystals are evenly dispersed in the treatment media allowing access to the proximal tubule epithelial cells lining the internal culture chamber within the kidney MPS to induce a physiological response to COM exposure. Investigating the cellular response to COM challenge in microgravity can provide insight into biochemical pathways of stone response in the kidney proximal tubule in microgravity and interrogate the mechanism of potassium citrate efficacy.” This article may be obtained online without charge.
Journal Impact Factor: 5.1
Funding: “This work was supported by the National Center for Advancing Translational Sciences (UH3TR000504, UG3TR002158 and UH3TR002178), jointly by the National Center for Advancing Translational Sciences and the Center for the Advancement of Science in Space (UG3TR002178), the National Institute of Environmental Health Sciences (P30ES00703 & T32ES007032) and an unrestricted gift from Northwest Kidney Centers to the Kidney Research Institute. BioServe’s work was supported in part by NASA contracts 80JSC020F0019 and 80JSC017F0129.”
3
Ra EA, Kim HB, Yun W, Bandaru A, Cho G, Lee S, Anderson MC, Kim MS, Kim H, Oh Y, Lee G.
Sex-specific changes in brain organoids from acute simulated galactic cosmic radiation are rescued by targeted ECM pathway stimulation .
Adv Funct Mater. 2025 Dec 7;e17942.
https://doi.org/10.1002/adfm.202517942
Journal Impact Factor: 27.7
Funding: “The authors gratefully acknowledge the Translational Research Institute for Space Health (TRISH/NASA) agency for their support (TSRAD 2020 and NNX16AO69A to G.L.) and this work was supported by the Translational Research Institute for Space Health through NASA Cooperative Agreement NNX16AO69A (G.L.).”
4
Plummer JT, Dezem FS, Cook DP, Park J, Zhang L, Liu Y, Marção M, DuBose H, Wani A, Wise K, Roach M, Harvey K, Wang T, Jensen KB, Morosini N, De Gregorio R, Alonso A, Houlihan SL, Schwartz RE, Hissong E, Snopkowski C, Wrana JL, Ryan N, Butler LM, Church G, Swarbrick A, Mason CE, Martelotto LG. @chm2042 @jip2007
Standardized metrics for assessment and reproducibility of imaging-based spatial transcriptomics datasets .
Nat Biotechnol. 2025 Dec 3.
https://doi.org/10.1038/s41587-025-02811-9
PI: C.E. Mason
Note: This article may be obtained online without charge.
Journal Impact Factor: 41.7
Funding: “C.E.M. thanks WorldQuant and GI Research Foundation (GIRF), NASA (80NSSC22K0254, 80NSSC24K0728, 80NSSC24K1052), the National Institutes of Health (P01CA272295, R01CA266279, U54AG089334), the UK Cancer Grand Challenges (SAMBAI), Blood Cancer United (MCL7001-18, LLS 9238-16, 7029-23/22, 7037-25), Boryung and Bumrungrad International Hospital.”
5
Tyson TL, Perez DF, Otero-Millan J.
Distortion of perceived visual space after prolonged horizontal eccentric gaze holding .
Vision Res. 2025 Dec 10;240:108729.
https://pubmed.ncbi.nlm.nih.gov/41380491
Note: From the abstract: “Eye movements have long been used as a measure of underlying brain function and pathology. Specifically, rebound nystagmus has provided a behavioral window into the adaptive mechanisms of gaze holding. It is an eye movement aftereffect resulting from maintaining gaze eccentrically for a prolonged duration. Upon returning to central fixation, the eyes drift or “rebound” back toward the previously held gaze location, demonstrating an adaptive process. Little is known about how prolonged eccentric gaze holding, and the accompanying adaptation of the oculomotor system, influences the perception of visual space. Here, we used a variant of the landmark task to assess spatial bias (or lack thereof) with and without prior eccentric gaze holding.”
Journal Impact Factor: 1.4
Funding: “This work was supported by the NASA Ames Research Center Graduate Fellowship Program, the Department of Veterans Affairs (VA) Veteran Readiness and Employment Program, National Institute of Health (NIH) R00EY027846 research project grant, and startup lab funds from the University of California, Berkeley.”
6
Galli A, Smith H, Blanc M, Foing B, Boithias H, Bolton SJ, Chung S, Coustenis A, Dautriat E, de Vera J-P, Doran P, Dubrulle F, Hesar FF, Frueh C, Garg S, Hedman N, Kim KJ, Lizy-Destrez S, Losch A, Marino A, McKay C, Michel P, Mousis O, Salmeri A, Shah U, R SS, Sims M, Worms J-C, Yano H.
Goals and trends in space exploration: An overview of the panel on exploration sessions at the committee on space research general assembly 2024 .
Life Sci Space Res. 2025 Dec 18. Online ahead of print.
https://www.sciencedirect.com/science/article/pii/S2214552425001488
Note: This is an Opinion/Position paper.
Journal Impact Factor: 2.8
Funding: H. Smith and C. McKay are affiliated with NASA Ames Research Center.
Physical Science papers deriving from NASA support:
7
Gangopadhyay AK, Beckers M, Schneider S, Sheng Y, Kelton KF.
Surface tension and viscosity of Zr 80****Pt 20 measured on the International Space Station and its implication on nucleation mechanism .
Metallurgical and Materials Transactions A. 2025 Nov 5.
https://doi.org/10.1007/s11661-025-08031-9
PI: K.F. Kelton
Note: ISS results.
Journal Impact Factor: 2.5
Funding: “Work at Washington University was supported by NASA grant 80NSSC21K1649. The authors acknowledge the access to the ISS-EML facility, which is a joint undertaking of the European Space Agency (ESA) and the DLR space administration.”
8
Thinnakornsutibutr N, Su A, Sharma A, Liao Y-T.
Fire scale modeling and effects of buoyant flow on laminar upward flame spread .
Appl Energy Combust Sci. 2025 Dec;24:100411.
https://doi.org/10.1016/j.jaecs.2025.100411
PI: Y-T. Liao
Journal Impact Factor: 6.0
Funding: “This research is supported by NASA Glenn Research Center (Award # 80NSSC22M0011), NASA Science Mission Directorate (Award # 80NSSC24K0310), and NSF (Award # CBET 1942282).”
9
Thomsen M, Fernandez-Pello C, Urban DL, Olson SL.
Extinction of opposed flame spread over thin paper .
Proc Combust Inst. 2025;41:105951.
https://doi.org/10.1016/j.proci.2025.105951
PIs: C. Fernandez-Pello, D.L. Urban, S.L. Olson
Journal Impact Factor: 5.2
Funding: “The work presented here was supported by NASA, United States Grants 80NSSC17M0065 and 80NSSC22K0582, and the project Agencia Nacional de Investigación y Desarrollo, ANID Fondecyt Iniciación, Chile 11240482.”
Other papers of interest:
1
Asrar FM, Sieber MA, Mukai C, Possnig C, Fardous MH, Williams DR, Morgan AR.
From bedside to orbit: The enduring impact of physician-astronauts over six decades of space exploration .
J R Soc Med. 2025 Dec 17;1410768251407760.
https://pubmed.ncbi.nlm.nih.gov/41403274
Note: From the abstract: “This article examines how physicians have helped shape human space exploration, and to articulate, from first-hand experience, why their medical training, scientific mindset and leadership abilities have played a significant role; and continue to offer relevance even as space exploration moves towards deep space and long-duration missions.” This article may be obtained online without charge.
2
Ellena G, Mazzoli A, Spacova I, Leys N, Lebeer S, Mastroleo F.
Meta-analysis of extremotolerant microbes to address nutrient deficiencies in bioregenerative life support systems during deep-space missions .
npj Sci Food. 2025 Dec 13.
https://pubmed.ncbi.nlm.nih.gov/41390500
Note: From the abstract: “Ensuring adequate nutrition is essential for long-duration space missions where Earth resupply is limited or unfeasible. Bioregenerative Life Support Systems (BLSS), such as ESA’s MELiSSA, aim to sustain astronauts by recycling resources and cultivating crops. However, plant-based diets in BLSS may lack key micronutrients. This study identified nutritional gaps in crop-based BLSS diets, revealing deficiencies in several micronutrients, including cobalamin (vit B₁₂), riboflavin (vit B₂), and calciferol (vit D). We screened microorganisms for genomic potential to produce these micronutrients and filtered candidates based on inclusion in the EFSA Qualified Presumption of Safety and Novel Food lists.” This article may be obtained online without charge.
3
Kourtidou-Papadeli C, Terzopoulos G, Kourtidou S, Dafli E, Karnaras D, Galanopoulou K, Theodorou E, Kontogianni A, Georgiou N, Bamidis PD, Vernikos J.
Counteracting inactivity deconditioning with graded hypergravity loading: From clinical neurorehabilitation to space medicine .
Life Sci Space Res. 2025 Dec 10. Online ahead of print.
https://doi.org/10.1016/j.lssr.2025.12.001
4
Ogneva IV.
The fruit fly Drosophila melanogaster remains a promising model organism for research in space biology .
Life Sci Space Res. 2025 Dec 17. Review. Online ahead of print.
https://doi.org/10.1016/j.lssr.2025.12.003
5
Xie J, Zhu J, Wang L, Jiao Y, Dou Y, Zhao Z, Luo B, Ha M, Zheng H.
Potential regulatory modules to integrate microgravity signals into flowering pathways in Arabidopsis thaliana grown in space .
npj Microgravity. 2025 Dec 13. Early access article.
https://pubmed.ncbi.nlm.nih.gov/41390682
6
Zhang Y, Cheng B, Jiang F, Baoyin H, Liu J, Zhan X.
Space sustainability via flexible controlled expandable net for multiple irregular debris removal .
Acta Astronaut. 2026 Mar;240:448-61.
https://doi.org/10.1016/j.actaastro.2025.11.063
7
Fais G, Ghiani F, Dessì D, Casula M, Perra G, Torchia E, Lai N, Cao G, Concas A.
Superfood potential of Chlorella vulgaris : Productivity and antioxidant boost under simulated Moon and microgravity conditions .
npj Microgravity. 2025 Dec 12. Early access article.
https://pubmed.ncbi.nlm.nih.gov/41387966
Note: A 3D clinostat was used in this study. This article may be obtained online without charge.
8
Schuerger AC, Soltez KSN, Paul AL, Ferl R.
Simulated microgravity enhances germ tube elongation by Golovinomyces cichoracearum on Cucurbita pepo and Arabidopsis thaliana leaves .
Phytopathology. 2025 Dec 15. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/41397306
Note: From the abstract: “Bioregenerative Life Support Systems (BLSS) are proposed for the production of food crops, water recycling, and air revitalization in future microgravity, Moon, and Mars habitats. The alternative hypothesis (Ha) for the current study was that simulated microgravity would increase phytopathogen growth rates potentially leading to increased levels of disease in space-based BLSS modules. Squash cotyledon leaf discs, and full canopies of Arabidopsis thaliana (At) plants, were dusted with conidia from 14-d-old colonies of Golovinomyces cichoracearum (Gc). Leaves were positioned into one of five gravity treatments including: (1) adaxial leaf surfaces pointed upward (1g-up control), (2) adaxial surface oriented 90° to Earth’s 1g down vector (1g-90° control), (3) adaxial surfaces pointed down (1g-down control), (4) rotated on a 2D clinostat, or (5) randomly rotated on a 3D random positioning machine (RPM).”
9
Šefic T, Prtenjak H, Oman S, Fidler A.
Effect of microgravity on the feasibility and accuracy of dental procedures .
npj Microgravity. 2025 Dec 13. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/41387709
Note: This article may be obtained online without charge.
10
Ullah I, Shakir MZ, Zhou XC, Liu J, Li S, Chen H, Jiang N, Usmani MW, Barkat MQ, Du Q, Zhao Y, Wang N, Liu X.
Effect of Hong Huang Tang on memory enhancement and mitigation of microgravity-induced oxidative stress in C. elegans .
Biogerontology. 2025 Dec 16;27:24.
https://pubmed.ncbi.nlm.nih.gov/41400846
11
Markiewicz M, Galanty A, Zagrodzki P, Kołodziejczyk A, Paśko P.
Searching for innovative functional foods: Correlation between chemopreventive potential and bioactive compounds accumulation in Brassica sprouts grown under altered gravity conditions .
Int J Mol Sci. 2025 Nov 22;26(23):11287.
https://pubmed.ncbi.nlm.nih.gov/41373447
Note: A random positioning machine was used in this study.
12
Ahmad F, Sinha A, Karim A, Srinivas M, Jose J, Tomar D, Qaisar R.
ER stress inhibitor 4PBA attenuates hindlimb unloading-induced cardiac mitochondrial and metabolic dysfunction .
Pflugers Arch. 2025 Dec 16;478(1):11.
https://pubmed.ncbi.nlm.nih.gov/41398096
13
Tomilovskaya ES, Puchkova AA, Rukavishnikov IV, Shigueva TA, Shpakov AV, Orlov OI.
The effect of dry immersion and head-down tilt bedrest of the same duration on the human body: First results .
Acta Astronaut. 2026 Mar;240:568-80.
https://doi.org/10.1016/j.actaastro.2025.12.016
14
Li Y, Wellmerling JH, Rosas L, Link PA, Chow D, Alvarez J, Choi KM, Diaz Espinosa AM, Gilbert RM, Goplen NP, Li D, Haak AJ, Prakash YS, Rojas M, Tschumperlin DJ.
Modulation of an aberrant basal cell program in human alveolar epithelial spheroids and lung slices subtitle: Modulating aberrant basal cells in human cells and tissues .
Respir Res. 2025 Dec 12.
https://pubmed.ncbi.nlm.nih.gov/41388287
Note: This article may be obtained online without charge.
15
Rose B, Moore D, Eskew J, Vanacore R, Hartson SD, Province D, Skaff DA, Smith A.
Tracking hemopexin intracellularly and defining hemopexin protein “interactomes” in human immune and liver cell models .
Front Physiol. 2025;16:1613917.
https://pubmed.ncbi.nlm.nih.gov/41384245
Note: This article may be obtained online without charge.