DNA damage response

AWG Discussions AI/ML AWG Topics
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Hi,
I’m a PhD student working on DNA damage and repair, if there is any project related to the topic kindly let me know.
Thanks

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Thanks for the post! I’ll introduce you to @ss.damianj @svcostes and Brian Evarts (once he joins)

Cheers!
-Ryan

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Hi! What is your project? We have several members working on various aspects of radiation and DNA damage, we can try to connect you with some researchers if you share some specifics?

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Hi,

Thank you very much for your email,

I’m doing my PhD on a protein called MITF (Protein involved in tanning response) and its role in maintaining genomic stability.

I’m new to this group, I’m not sure how it works. However, I intend to work in the field of space biology and astrobiology.

I would be very happy if you could connect me with people in a similar field.

Thank you

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I believe that @anarayan09 has experience working with osteoclasts and osteocytes, which show overexpression of MITF in simulated microgravity. Maybe there is an interesting discussion about the relationship between microgravity and MITF that could be initiated?

Do you have ideas for how you might relate your research to the field of space biology? This could help us narrow down potential collaborators/people to network with. It seems like most literature related to MITF and radiation is related to UV radiation, which is non-ionizing. I am not sure if there is any literature relating these transcription factors to space-relevant ionizing radiation, such as protons/proton therapy used for the treatment of melanoma (the context in which MITF seems to be studied most).

Rachel

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Thank you for this,

Based on our observations, MITF appears to be significantly involved in the DNA damage response. However, this is unpublished data, so I cannot share detailed information at this time. We have also noted changes in MITF expression following UV damage, which is very intriguing. Additionally, I am collaborating with a yeast biologist to explore whether MITF has an evolutionary role in initiating the DNA damage response to UV-induced damage.
I am also considering how MITF might be involved in UV-induced damage. If MITF plays a role in regulating or sensing UV-induced damage, this could have implications for space biology. In space, the absence of an ozone layer results in much higher levels of dangerous UV radiation. Understanding MITF’s role could provide insights into how UV exposure affects the genome and the potential for life in the form of DNA.

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I’m also very interested in stem cells.
You mentioned that there is overexpression of MITF in simulated microgravity in osteoclasts and osteocytes. that makes me think if MITF has any in bone regeneration, we can probably check this by MSC differentiation to osteocytes and chondrocytes in the presence or absence of MITF, to see its effect.

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Hi @tbv1 we have a sub group that its working in a project in AI-Ml AWG about using ML Methods for DNA Damage for Microscopy Images. I can put you into contact with @Brian_Evarts if you would like to talk more about the project goals.

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Hi,

Thank you very much, that would be great.

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@evartsb check out this thread