Dear all,
I am interested in characterizing microenvironment changes upon altered gravity and cosmic radiation.
I am starting with data-mining in the brain, but in the future I want to compare it to other organs. If you are interested and would like to collaborate on this let’s connect!
Best wishes
10 Likes
Have you raised this in the @AnimalAWG with @paula6 as chair of the group - I think a number of people would be intersted, and some ground work may already be worthy to follow up on. @stefania.giacomello @upal.roy @jderivero
2 Likes
I haven’t, thank you for the heads up!
1 Like
@m.trombetta.lima we have our monthly meeting today - let’s discuss some more.
2 Likes
I’m waiting for responses to this:
https://awg.osdr.space/t/eeg-data-on-space-conditions/648
But I suppose you are minning something like this:
https://genelab.nasa.gov/search/node?keys=brain
I’m primarily interested in Homo sapiens, but while I’m waiting for a response, it might be useful for me to review data on other species as well. If you need anything, perhaps I can collaborate with you.
2 Likes
Hi,
Yes. I am interested on looking into that.
Just in case, my e-mail is jderivero@med.miami.edu.
Best,
Pablo.
2 Likes
Let me tag a few folks here who could be interested: @solene.frapard , @stefania.giacomello, @asaravia. The four of us are working on brain data and it would be great to have your insight about aging processes and ECM changes in this context.
3 Likes
have you looked at low dose radiation as a model for accelerated aging?
1 Like
@mpecaut share this in zoom:
1 Like
I am interested in other organs, such as the bone marrow microenvironment, so would love to connect and collaborate.
Best,
Jaira
3 Likes
@m.trombetta.lima, here are some datasets in OSDR that may be of interest: OSD-561/GLDS-556, OSD-562/GLDS-557, OSD-563/GLDS-558, OSD-564/GLDS-559, OSD-612/GLDS-588, OSD-613/GLDS-589, OSD/GLDS-352, and OSD/GLDS-525. As Sylvain mentioned above, we currently have a collaborative project with @stefania.giacomello 's group (lead by @solene.frapard) to analyze the RRRM-2 and RR-10 brain spatial transcriptomics data.
4 Likes
As @svcostes and @asaravia mentioned we are currently working on the analysis of RRRM-2 and RR-10 brain spatial transcriptomics and snMultiomics data, it would be interesting to have a chat!
My email is: solene.frapard@scilifelab.se
Best,
Solène
3 Likes
@solene.frapard @stefania.giacomello
Marina introduced herself and her work at the the @AnimalAWG yesterday.
I forgot when exactly, but coming meeting will have a deep dive. and will be doing a more substantive presentation at future meeting
The Animal AWG hub has meeting notes link: https://awg.osdr.space/g/AnimalAWG
5 Likes
Yes the initial wording of the question reminded me of CHROMEX and the work that Mary Musgrave lead on plant reproduction in space. Mary had an environmental stress ecophysiology approach and as part of this work I started looking into the biophysical domain with oxygen microsensors looking at cellular microenvironments associated with indirect microgravity diffusion stress. That is why my research went into biophysical methods for cellular and mitochondrial biophysics. I started looking at oxygen using electrochemical microelectrodes, and went on to develop and deploy a wide range of probe and lab-on-a-chip technologies for (peroxide, NO, K+, H+, Ca++, glucose, glutamate, neurotransmitters!)… we have a hole library of redox, ion, and biosensor based probes for studying and interrogating biophysical transport in the cellular microclimate domain. I am always happy to help and collaborate on any relevant space related research. I make these tools available to the community to collaborate or use to advance the field of space biophysics. Please access my google Scholar page ( D. Marshall Porterfield - Google Scholar ) and you will see sensors and affiliated biophysical methods deployed across a diverse array of model research systems. Everything from biofilms, beta cells, neurophysiology, cancer and gravitropic Ca/No/cGMP signaling! The reason I went into biosensors was because of the need to understand biophysical transport in the cellular microenvironment domain. I am happy to consult and collaborate on any project with good science to be explored in space biology where my abilities can be applied. My approach has always been based on “hypothesis driven engineering” to deliver advanced research capabilities to unlock the “impossible experiment.” That is the approach that ultimately inspired Genelab! Marshall Porterfield
2 Likes
@solene.frapard @stefania.giacomello @m.trombetta.lima @rtscott2001 @szewczyk
Marina will plan to present more at the September Animal AWG meeting - hope to see you then!
3 Likes
Hi @m.trombetta.lima
You should consider applying to ESA open ideas. https://shorturl.at/wpkB5
This is a very interesting topic.
1 Like
Hi Marina,
I saw your quick presentation during the meeting in August, and really liked the work you plan to do. I would love to be a part of it. Is there a group meeting you have that I can join?
1 Like
Must have missed the meeting introducing your work. However, I am very interested to join! My email is mjr5770@uncw.edu. Hope to connect.