AWG PD and Brain Aging Subgroup

Hi everyone,
I’m excited to invite you to join the AWG PD subgroup, with the goal of making it more accessible to the broader scientific community. We focus on the analysis of multi-omics data from spaceflight and its comparison with Parkinson’s disease (PD) patient data from MJFF’s PPMI and other publicly available datasets, with a strong emphasis on brain aging and PD-like neurodegenerative risk.

Our subgroup was launched in early 2024 and brings together researchers interested in effect of exposome, such as microgravity and radiation on the brain, PD biomarkers, and aging-related vulnerability due to spaceflight environments.

We welcome individuals from diverse backgrounds, including molecular biology, neuroscience, computational biology, AI/ML, and systems medicine.

:dna: What we do:

  • Analyze omics data from rodent brain, human, and neuronal models exposed to spaceflight and space analog stressors
  • Compare these findings to clinical PD datasets to identify convergent molecular signatures
  • Curate custom PD and aging-related pathways
  • Explore data-driven hypotheses on the intersection of radiation, aging, and neurodegeneration

We already have several active and upcoming projects—some open to new collaborators—and are working on multiple publications.

:books: Here’s a link to recent publications and presentations on this topic from our subgroup and my lab.

https://www.nature.com/articles/s41526-024-00457-6

More exciting work is underway!

:spiral_calendar: We meet biweekly on Mondays at 9 AM MST (subject to change soon)

:envelope_with_arrow: If you’re interested in joining, contributing, or just learning more, please DM me or email at nilufarali@boisestate.edu.

Let’s work together to uncover the shared mechanisms behind PD and spaceflight exposure—and develop strategies to mitigate the risk.

@MultiOmicsAWG

10 Likes

Thank you for the invitation. I am particularly interested in this research direction and would be honored to join your team.

---- Replied Message ----

From | Nilufar Ali via Open Science Data Repository Analysis Working Groupsnotifications@osdr.discoursemail.com |

  • | - |
    Date | 06/13/2025 06:47 |
    To | waq15554811171waq15554811171@163.com |
    Subject | [Open Science Data Repository Analysis Working Groups] [AWG Projects/Multi-Omics AWG Open Projects] AWG PD and Brain Aging Subgroup |

| nilufarali AnimalAWG
June 12 |

  • | - |

Hi everyone, I’m excited to invite you to join the AWG PD subgroup, with the goal of making it more accessible to the broader scientific community. We focus on the analysis of multi-omics data from spaceflight and its comparison with Parkinson’s disease (PD) patient data from MJFF’s PPMI and other publicly available datasets, with a strong emphasis on brain aging and PD-like neurodegenerative risk. Our subgroup was launched in early 2024 and brings together researchers interested in effect of …

2 Likes

Hello, I developed a very accurate tool for identifying brain pathologies based on resting-state EEG. In fact, it works very well for Parkinson’s, and since it’s EEG, it’s very cheap, simple, and allows for highly precise identification of states in real time. This would make experiment design and data cross-referencing with other methods much easier. Here’s the link:

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Could I please ask how this is different to the brain ageing and Alzheimers group?
I just don’t want to double up my time is all as I’m calling in from Australia.

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Wonderful!

Thanks for sharing this!

Hi, this is the PD sub group and we are looking at curated hallmark aging pathways from PD patients data, PD specific brain regions of mice and comparing them post spaceflight. And I believe Joe is leading the work on sex-specific aging related changes in the AD sub group.

Hi! It’s so great to meet you. I’d be excited to join your team, this project really aligns with my previous research experiences, and I’d love to contribute.

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Hello Nilufar,

I would like to contribute to the Parkinson’s Disease subgroup.
Thank you for your consideration and time.

Kind regards,

Hasret

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I would be interested in joining to learn more about how I can help advance this interesting new AWG.

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I hereby inform of my interest to join the group.
I have interest in identifying pathways, biomarkers, and representative classifier genes from analyses of omics data – RNA-Seq, microarray, …

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Hi Nilufar,
I would like to contribute to the Parkinson’s Disease subgroup. Please add me to the group also. Is there any monthly meeting also? Thank you

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Hi also wondering if there was any way I could contribute

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Hi, welcome aboard!
I look forward to seeing you in our next Zoom meeting. Please see the calendar link posted above. Thanks!

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Hi all,
Thank you for attending the Zoom meeting today. Here is the link to the member’s list. New members please add your names and other details here: https://docs.google.com/spreadsheets/d/1WajNl7_R-DrNJOtauKarNQqGM5d5nUtygJd-dq3FaY4/edit?gid=0#gid=0 I will include you in the follow up emails.
Regards,
Nilufar

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Hi Dr. Ali,
I would love to contribute to the project if you are accepting more collaborators. My email is mtole014@ucr.edu

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Excellent thanks Marc! Welcome to the AWG :blush:

Make sure to ping @windymc and @nilufarali

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Hi Marc, welcome to the group! Please email me at windymc@stanford.edu if you are interested in helping out with AD research. Otherwise, Nilufar is running the Parkinson’s group and is great to work with too!

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Hi Marc, please join the meeting tomorrow!

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