Proposal to NASA: Investigating the Use of IV Lecanemab in Rats in Microgravity to Remove Amyloid Beta Plaque with and without Ultrasound to Open the Blood-Brain Barrier and its implications for Astronauts on long duration missions to Mars.
By David Barckhoff University of Pittsburgh
This proposal outlines a research study to investigate the efficacy of intravenous (IV) lecanemab in reducing amyloid-beta (Aβ) plaque in rats exposed to microgravity, both with and without focused ultrasound (FUS) to transiently open the blood-brain barrier (BBB). The study aims to assess the implications of these findings for astronauts undertaking long-duration missions to Mars, where microgravity exposure and potential neurodegenerative risks are significant concerns.