Proposal to NASA: Investigating the Use of IV Lecanemab in Rats in Microgravity to Remove Amyloid Beta Plaque with and without Ultrasound to Open the Blood-Brain Barrier and its implications for Astronauts on long duration missions to Mars.
By David Barckhoff University of Pittsburgh
This proposal outlines a research study to investigate the efficacy of intravenous (IV) lecanemab in reducing amyloid-beta (Aβ) plaque in rats exposed to microgravity, both with and without focused ultrasound (FUS) to transiently open the blood-brain barrier (BBB). The study aims to assess the implications of these findings for astronauts undertaking long-duration missions to Mars, where microgravity exposure and potential neurodegenerative risks are significant concerns.
This drug causes micro bleeds and swelling in humans it is not a good way to approach this. It also does not deal with the process of this disease, that is far more complicated. Tau &Amyloid is really a dead end. Look at the research of Peter at Northwestern. It appears in Nature if you want a therapy that doesnt cause any of the problems of lecanemab. Look at this latest human trial: https://nkgenbiotech.com/wp-content/uploads/2026/03/ADPD-2026-NKGen-Presentation-March-2026.pdf