Hello all,
Are there any ongoing studies using C. elegans or zebrafish to explore the effects of simulated microgravity? I’m interested in learning about how these organisms are used, the methods involved, and what discoveries have been made. Understanding the goals and outcomes of these studies would be really insightful. Also, I’m very open to discussing potential collaboration opportunities in this area of research.
Dr Vinothkannan Ravichandran
Amity Centre of Excellence in Astrobiology
Amity University Maharashtra, Mumbai.
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Hi there. Here are a few references that could be helpful:
For C. elegans, @szewczyk was involved with this microgravity review (which includes references to several simulated microgravity studies), and he can probably provide some information about methodology, or at least some resources.
For zebrafish, we have a couple of simulated microgravity studies deposited in OSDR:
OSD-373 and OSD-76. But there are many other studies using zebrafish in SMG that we do not currently host in our repo:
Carvajal-Agudelo et al. 2024
Carvajal-Agudelo et al. 2023
Carnovali et al 2024
I don’t believe that the authors of these papers are members of our AWG groups, but I hope that the publications might be useful references for methodology. We have several members with experience using simulated microgravity devices for other organisms, if you find yourself with questions about the devices themselves (clinostat, rotating wall vessel, random positioning machine, etc).
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Hello Dr. Rachel,
Thank you so much for the information. I will look into the suggested articles.
With regards
VK
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Hi Vinothkannan,
Sorry for the lag. Probably the best people to talk to about simulated microgravity and worms are: Atsushi (｜Graduate School of Life Sciences Tohoku University) or Jin (http://wonjuworm.org). If you want actual spaceflight that’s probably Atsushi or me.
Hope this helps,
-nate
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Dear Nate,
Thank you so much for the information.
-VK
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Dr. Andrea Henle is involved with Zebrafish research, but more for cancer. She has done some work with clinostats and zebrafish.
Dr. Gary Stutte has done some work with C.elegans in the context of compost for bioregenerative life support systems.
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