Shape analysis identifies fat droplet subtypes in fatty liver disease

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A student I mentored applied my shape analysis algorithm to quantify phenotypes of fat droplets in fatty liver disease. See her video below. She would be happy to collaborate with people to analyze their data set.

Below are two papers showing the how microgravity induces a fatty liver phenotype. One of them uploaded data to OSDR!

Uncovering Hidden NAFLD Subtypes Through Fat Droplet Shape Analysis - by Cinty Lin [12 min] https://youtu.be/Nsct3nB8sRw.

Here is the link to the paper Cinty Lin published in a student journal: https://doi.org/10.70251/HYJR2348.41422429.

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Spaceflight Activates Lipotoxic Pathways in Mouse Liver

Karen R Jonscher et al. PLoS One. 2016.

Data: OS-787
Microgravity May Detrimentally Influence Lipid Metabolism

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Shear flow alleviates spaceflight-induced hepatic lipid dysregulation via suppression of SREBP mechanotransduction

Ning et al. Science Bulletin 2026

https://www.sciencedirect.com/science/article/pii/S2095927326001167?via%3Dihub

@AnimalAWG @AIMLawg

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Hi @dave,

I just saw her video and the research is really interesting. I would love to learn, collaborate, and help analyze the dataset.

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Hi Swathiga, What is your email? Email me at dave@tsg-lab.org and I will connect you to Cinty. You should look into how to download the data for OSDR and become familiar with the types of images that they have. Based on the quality of the images, we will decide on how to best segment the fat droplets.

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Hi Dave,

Thanks for the response. I’d love an intro to Cinty. My email is swathigadevic@vt.edu.

I’ll start downloading the OSDR data and getting familiar with the image types so we can figure out the best segmentation approach. Happy to hop on a call once I’ve looked through a few datasets.

Best,
Swathiga

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