This is a longstanding listserve of articles relevant to space biology, space health, etc
Everything below is directly from that listserve:
SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at SPACELINE Current Awareness. Please send any correspondence or request to unsubscribe to Shawna Byrd, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.
Papers deriving from NASA support:
1
Hong X, Dalouchi F, Prom JC, Ponte ME, Hockey BL, Braun JL, Nies P, Stoltz A, Chakravarthi VP, Sinha M, Choi SY, Ronca AE, Alwood JS, Fajardo VA, Morris EM, Puukila S, Christenson LK. @vfajardo @lchristenson
Female reproductive dysfunction and transgenerational consequences following prolonged spaceflight exposure.
Proc Natl Acad Sci USA. 2026 Jul 7;123(27):e2606092123.
https://pubmed.ncbi.nlm.nih.gov/42378286
PI: L.K. Christenson
Note: ISS results. From the abstract: “Spaceflight presents unique gravitational, radiation, and isolation hazards for human exploration of the Moon, Mars, and beyond, yet its impact on the female reproductive system and successive generations has been largely unassessed. In the NASA Rodent Research 20 mission, we examined the impact of a 42-d spaceflight on the female reproductive axis including ovulatory capacity, implantation rate, and fecundity as well as behavioral, metabolic, and functional outcomes in F1 and F2 offspring.”
Journal Impact Factor: 9.5
Funding: “NASA Space Biology grant #NNX15AB48G/#80NSSC24M0072 (PI: L.K.C., Co-I A.E.R., J.S.A., and S.P.); Secondary Funding: NASA Ames Research Innovation Award (A.E.R, J.S.A, and S.P.); NIH COBRE P20GM144269 and University of Kansas Diabetes Institute Pilot Grant (E.M.M.); NASA 8ONSSC20M0109 (Kansas Space Grant Consortium Fellowship (P.N.); NSERC Alliance International Catalyst Grant ALLRP 591061 and Canadian Space Agency Grant 21HLSRM01 (V.A.F.); NSERC CGS-D awards (B.L.H. and J.L.B.).”
2
Casaletto JA, Scott RT, Rathod A, Jain A, Chandar A, Adapala A, Prajapati A, Nautiyal A, Jayaraman A, Boddu A, Kelam A, Jain A, Pham B, Shastry D, Narayanan D, Kosaraju E, Paley E, Uribe FP, Shahid I, Ye I, Wu J, Lin J, Srinivas K, Paolieri Della Monica M, Hitt M, Lin M, Volkan M, Kharya M, Kaul M, Jaffer MA, Ali M, Chang NZ, Ashri N, Couderc NB, Paladugu P, Sood R, Hiremath R, Pathak R, Dogra S, Srinivas S, Samaddar S, Gopinath S, Sawant S, Cai S, Pala V, Nair V, Shi Z, Anand Narayanan S, Thomas DM, Lewkowicz A, Waisberg E, Ong J, Gebre S, Galazka JM, Vaishampayan PA, Sanders LM, Mao XW. @james.casaletto @rtscott2001 @ongjo @gebresg @jgalazka @lauren.sanders
Machine learning ensemble reveals distinct molecular pathways of retinal damage in spaceflown mice.
npj Microgravity. 2026 Jul 3. Early access article.
https://pubmed.ncbi.nlm.nih.gov/42399270
PI: X.W. Mao
Note: GeneLab is available at https://genelab.nasa.gov. This article is available online without charge.
Journal Impact Factor: 5.1
Funding: “Funding from a NASA Transform to Open Science grant awarded to LMS, JAC, RTS, and PAV (NASA; 22-TOPST22-0020) supported the development of an on-demand open access course on AI/ML for Space Biology (https://www.nasa.gov/using-ai-ml-for-space-biology-research/). The creation of that curriculum led to this student cohort, citizen science, AWG community supported investigation. XWM was a principal investigator from Rodent Research-9 which was supported by NASA Space Biology grant #NNX15AB41G and LLU Department of Basic Sciences. The authors would like to thank the NASA Biological and Physical Sciences Division for supporting NASA Ames Life Sciences Data Archive, NASA GeneLab, and its umbrella project the NASA Open Science Data Repository. While this paper was not completely organized as one of the open projects of the OSDR-Analysis Working Groups, a number of the authors are AWG members and credit is due. We are grateful for all discussions and contributions especially from the Causal Inference Subgroup of the OSDR-AI/ML AWG. RTS and JAC are both part of the ‘AI for Life in Space’ group of researchers at NASA Ames and are grateful for the support from the NASA Science Mission Directorate’s ‘Foundation Model’ effort.”
3
Yin Y, Xu R, Makarczyk MJ, Liu JJ, Liu S, Shi MZ, Carlo RD, Almeida MF, Garris A, Day S, Sanchez-Hodge R, Schisler JC, Zilberman AH, Allen NG, Kubik AJ, Blaber EA, Olali AZ, Xie W, Wallace DC, Mason CE, Alexander PG, Intini G, Beheshti A, Lin H. @ajkubik12 @blabee @chm2042 @AfshinBeheshti
Kaempferol attenuates spaceflight-associated knee cartilage degradation by targeting NOX4-mediated mitochondrial dysfunction.
Adv Sci (Weinh). 2026 Jul 9;e76477.
https://pubmed.ncbi.nlm.nih.gov/42423501
PI: A. Beheshti
Note: From the abstract: “Microgravity and space radiation experienced during spaceflight have adverse effects on musculoskeletal health, yet their impact on articular cartilage has not been fully understood. In this study, we demonstrated that simulated spaceflight on Earth leads to cartilage degradation in the knees of mice.” This article is available online without charge.
Journal Impact Factor: 14.1
Funding: “This work was supported by the Department of Orthopedic Surgery and the Orland Bethel Family Musculoskeletal Research Center (BMRC) at the University of Pittsburgh School of Medicine. A.B. was supported by research funding from the NASA E.9 Space Biology Research Studies 2023 grant. Otsuka Pharmaceutical Co., Ltd. provided additional funding to A.B. for conducting space-simulated mouse experiments involving kaempferol. Part of the work was supported by DOD W81XWH-21-0128 grant PR202887 and NIH grants 1R01CA259635 and 1R01AG078814awarded to D.C.W., and by the University of Pittsburgh Center for Research Computing through the resources provided. Specifically, this work used the HTC cluster, which is supported by NIH award number S10OD028483. We also acknowledge the International Space Station National Laboratory and RevBio Inc. for kindly contributing the knee tissue samples from the RR-25 Mission (grant agreement # GA-2020-0983).”
4
Lakey BD, Wozniak KJ, Britton RA, Tabor JJ.
Mucin-derived sugars act as metabolic brakes controlling growth initiation in Akkermansia muciniphila.
Gut Microbes. 2026 Jun 26;18(1):2691334.
https://doi.org/10.1080/19490976.2026.2691334
PI: K.J. Wozniak
Note: This article is available online without charge.
Journal Impact Factor: 11.0
Funding: “This work was supported by funding from NIH (NICHD) R21 HD111910-01 (JJT) and NIH (NIAID) U19 AI157981 (RAB). KJW was supported by the Translational Research Institute for Space Health through Cooperative Agreement NNX16AO69A and a training fellowship from the Gulf Coast Consortia, on the Antimicrobial Resistance Training Program in the Texas Medical Center (AMR-TPT; NIAID Grant No. T32 AI179595). We would like to thank Dr. Kunal Rai (MD Anderson Cancer Center) for providing strain MDA JAX-AM001.”
5
Lin YY, Esswein P, Ramirez L, Warren E, Nicenboim J, Gerecht S.
Derivation of functional retinal endothelial cells from human pluripotent stem cells for therapeutics and modeling.
Nat Biomed Eng. 2026 Jun 30.
https://pubmed.ncbi.nlm.nih.gov/42380331
PI: S. Gerecht
Note: This article is available online without charge.
Journal Impact Factor: 26.3
Funding: “…This work was supported by SNT0101 from the Translational Research Institute through the NASA Cooperative Agreements NNX16AO69A and EY035853 (both to S.G.).”
__________________________________________________
Other papers of interest:
1
Buckey JC Jr. @jay.buckey
Head-down tilt bedrest-A problematic weightless analog for SANS.
JAMA Ophthalmol. 2026 Jun 18. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/42313415
Note: This article is an Invited Commentary which highlights the JAMA Ophthalmol article titled, “Repeat exposures to spaceflight or bedrest and spaceflight-associated neuro-ocular syndrome findings” (https://doi.org/10.1001/jamaophthalmol.2026.2140) that appeared in Current Awareness list #1,205.
2
Dvorak C, Buckey JC Jr. @jay.buckey
Large language models as behavioral health teammates in long-duration spaceflight.
Aerosp Med Hum Perform. 2026 Jul 1;97(7):516-23.
https://pubmed.ncbi.nlm.nih.gov/42386193
Note: From the abstract: “Long-duration spaceflight exposes crews to isolated, confined, and extreme environments where chronic stress and limited real-time support heighten interpersonal tensions. Large language models (LLMs) could serve as onboard artificial intelligence teammates for de-escalation, but could also exacerbate tensions by endorsing hostility or exclusion. This study evaluates whether LLMs demonstrate prosocial conflict mediation behaviors vs. failure modes that could elevate interpersonal risk.”
3
Sandal GM, Smith N.
Value dynamics and interpersonal tension among astronauts during International Space Station missions.
PLoS One. 2026 Jul 8;21(7):e0351965.
https://pubmed.ncbi.nlm.nih.gov/42418391
Note: From the abstract: “Astronauts’ ability to maintain motivation over extended periods is crucial for space mission success. This paper examines how motivational goals (personal values) change during space missions and explores the associations between perceived value congruence and intra-crew tension among astronauts staying 4-7 months at the International Space Station.”
4
Maltese F, Steinberg J, Schultz J, Hodkinson P, Runswick OR.
Feasibility of real-time astronaut eye-tracking during analog extravehicular activities.
Aerosp Med Hum Perform. 2026 Jul 1;97(7):543-9.
https://pubmed.ncbi.nlm.nih.gov/42386184
Note: From the abstract: “As lunar missions increase in frequency and duration, astronauts will conduct more extravehicular activities (EVAs) under demanding conditions that elevate workload, reduce situational awareness, and heighten the risk of operational errors. Despite extensive use in other high-risk fields, eye-tracking technology has not yet been applied to assess gaze behavior during EVAs. We evaluated the feasibility of using mobile eye-tracking within analog EVA suits, focusing on implementation, data quality, livestreaming capability, and the ability to compare gaze behavior across tasks and suits.”
5
Steinhagen B, Albrecht UV.
SArES: A modular edge-based SCG processing framework for space-oriented cardiovascular monitoring.
Stud Health Technol Inform. 2026 Jun 29;338:201-5.
https://pubmed.ncbi.nlm.nih.gov/42393991
Note: From the abstract: “Continuous cardiovascular monitoring is essential in demanding environments such as space missions, where physiological changes may occur under microgravity and radiation exposure. Seismocardiography (SCG) provides a non-invasive approach for monitoring cardiac activity using wearable accelerometer-based sensors, but the signals are highly sensitive to motion artifacts and environmental influences. This paper presents SArES, a mobile edge-based application for the acquisition, processing, and visualization of SCG signals.”
6
Adams B, Levinson Z, Alexandrov P, Mampre D.
A closed-system lumbar puncture design for microgravity.
Aerosp Med Hum Perform. 2026 Jul 1;97(7):534-8.
https://pubmed.ncbi.nlm.nih.gov/42386172
Note: From the abstract: “A lumbar puncture (LP) is a diagnostic and therapeutic procedure for wide-ranging conditions terrestrially with additional applications in the microgravity environment of human spaceflight. LP has been performed on astronauts postflight in an attempt to answer lingering health questions, like the causes of spaceflight-associated neuro-ocular syndrome. However, an LP has not been performed in space or microgravity before due to the operational constraints of the procedure, including infection risk, air entrance, and fluid management difficulties in microgravity. This has prevented in-flight intracranial pressure measurements and important characterizations of cerebrospinal fluid (CSF) composition during spaceflight.”
7
Côté M, Smith D, Orozco N, VanBerlo B, Huggard B, Arntfield R, Prager R.
Artificial intelligence interpretation of point-of-care lung ultrasound in microgravity.
Aerosp Med Hum Perform. 2026 Jul 1;97(7):505-9.
https://pubmed.ncbi.nlm.nih.gov/42386183
Note: From the abstract: “LUS clips were acquired from two healthy volunteers during parabolic flight maneuvers simulating microgravity and lunar gravity, with +1-G clips used as controls. Clips were analyzed using an AI model to classify the presence of lung sliding and model performance and confidence were compared across gravity conditions. All clips were reviewed by an expert to establish whether lung sliding was present, which served as the reference standard for AI model evaluation.”
8
Park SY, Park S, Park HJ, Park H, Lee BJ, Kim S, Chun YS.
Time-averaged simulated microgravity ameliorates tau-induced deficit in Drosophila melanogaster.
npj Microgravity. 2026 Jul 1. Easy access article.
https://pubmed.ncbi.nlm.nih.gov/42386756
Note: A two-axis clinostat was developed to simulate microgravity. This article may be obtained online without charge.
9
Neriishi K, Richardson RB.
Intermediate risk factors in ionizing radiation cataractogenesis.
Ann ICRP. 2026 Jul 7;1466453251412608. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/42411746
10
Dillon GA, Webb KL, Uchida K, Wiggins CC, Senefeld JW, Shepherd JRA, Buchholtz ZA, Baker SE, Trenerry MR, Haider CR, Holmes DR, Joyner MJ, Curry TB.
Cognitive performance during acute hypoxia is associated with cerebral oxygenation and blood flow.
Aerosp Med Hum Perform. 2026 Jul 1;97(7):496-504.
https://pubmed.ncbi.nlm.nih.gov/42386185
11
Hou HR, Zhang TT, Liu YW, Cai LK, Huang Y, Wang R, Wang HY, Biekan J, Qiao PG, Yang ZH, Wang ZC, Ren PL, Zhao PF.
Lateralized cerebral arterial blood flow and blood pressure adaptations to short-term head-down tilt: A 4D flow MRI study with cognitive function assessment.
Mil Med Res. 2026;13(1):100048.
https://pubmed.ncbi.nlm.nih.gov/42382465
Note: This article may be obtained online without charge.
12
Edwards AM, Or PPL, Hou CW, Huang CY, Zheng C, Sun F, Liu X, Masodsai K, Kuo CH.
Damage-induced muscle regeneration after exercise in humans: Modulatory effects of ginsenoside Rg1.
J Tradit Complement Med. 2026 Jul;16(4):355-61.
https://pubmed.ncbi.nlm.nih.gov/42382056
Note: This article may be obtained online without charge.
13
Krämer CL, Arndt F, Boschert AL, Walkenfort B, Leuko S, Hasenberg M, Beblo-Vranesevic K, Döscher-Siems K.
Bacterial resistance across habitats: From German schools to the International Space Station.
Front Microbiol. 2026 Jun 18;17:1849378.
https://pubmed.ncbi.nlm.nih.gov/42395912
Note: This article is part of Research Topic “Microbial Interactions: from Mechanisms to Applications in the Fight Against Antimicrobial Resistance” (https://www.frontiersin.org/research-topics/73204/microbial-interactions-from-mechanisms-to-applications-in-the-fight-against-antimicrobial-resistance) and may be obtained online without charge.
14
Uchiumi M, Navarette N, Hughes J, McArdle J, Nithyanandam S, Caruso J, Best S, Bollinger LM.
Unilateral lower limb suspension impairs balance and firing rate of soleus small motor unit action potential trains during single leg stance.
Med Sci Sports Exerc. 2026 Jul 7. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/42406559
Note: From the abstract: “Postural control, which is largely determined by coordinated activation of dorsi- and plantar-flexors, is impaired following spaceflight. Unilateral lower limb suspension (ULLS) mimics spaceflight-induced reductions in motor unit recruitment, but its effects on balance are unknown.”
15
Wakigawa T, Kimura Y, Mito M, Tsubaki T, Lee M, Nakamura K, Khan AH, Saito H, Yamamori T, Yamazaki T, Higashibata A, Tsuboi T, Hirabayashi Y, Takeuchi-Tomita N, Saito T, Higashitani A, Shichino Y, Iwasaki S.
Gravitational and mechanical forces shape mitochondrial translation.
Nat Commun. 2026 Jun 30;17(1):5552.
https://pubmed.ncbi.nlm.nih.gov/42380108
Note: From the abstract: “Life on Earth has evolved in a form suitable for the gravitational force. Although the pivotal role of gravity in gene expression has been suggested, the molecular details remain unclear. Here, we show that mitochondria utilize gravity to activate protein synthesis within the organelle.”
16
Liu S, Wang W, Wang W, Xie B, Liu H, Liu H.
Building a living soil on Mars: Sequential phytoremediation and bioreduction of perchlorate in regolith simulants.
Acta Astronaut. 2026 Jul 7. Online ahead of print.
https://doi.org/10.1016/j.actaastro.2026.06.066
Note: From the abstract: “Future applications of Bioregenerative Life Support System (BLSS) in crewed Mars exploration will inevitably involve the development of in-situ resource utilization (ISRU) on Mars. Martian regolith represents a key target for agricultural ISRU on Mars. However, its application is severely limited by poor physicochemical properties, lack of organic matter, and perchlorate contamination. This study proposes a biological improvement strategy for Martian regolith: ‘plant-mediated organic matter accumulation + Microbial perchlorate removal.’”