SPACELINE Current Awareness - Publication list April 17, 2026

This is a longstanding listserve of articles relevant to space biology, space health, etc

@AWGall

Everything below is directly from that listserve:

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at SPACELINE Current Awareness. Please send any correspondence or request to unsubscribe to Shawna Byrd, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.

Papers deriving from NASA support:

1

Koch EJ, Conesa A, Garrett TJ, Ormsby R, Bohl R, Reed DW, Foster JS.

Beneficial microbes mitigate molecular stress responses and accelerate developmental pathways in host animals during spaceflight .

Front Space Technol. 2026 Mar 17;7:1791484.

https://doi.org/10.3389/frspt.2026.1791484

PI: J.S. Foster

Note: This article may be obtained online without charge.

Journal Impact Factor: 1.3

Funding: “The author(s) declared that financial support was received for this work and/or its publication. This work was supported by a NASA Space Biology Award 80NSSC19K0138 awarded to J.S.F.”

2

De Rudder C, Greenhalgh K, Baginska J, Martin-Gallausiaux C, Grandmougin L, Villette R, Lucchetti M, Hansen B, Ostaszewski M, Petrov VA, Atarashi K, Weidert L, Frachet Bour A, Ternes D, Ramiro-Garcia J, Malabirade A, Tanoue T, Mac Giolla Eain M, Letellier E, Barrett M, Lacombe J, Zenhausern F, Guérin C, Ollert M, Seguin-Devaux C, Honda K, Wilmes P.

immunoHuMiX: A personalizable gut-on-chip model for unraveling human microbiome–immune interactions .

VIEW. 2026 Mar 24;20250213.

https://doi.org/10.1002/VIW.20250213

PI: F. Zenhausern

Note: This article may be obtained online without charge.

Journal Impact Factor: 8.5

Funding: “…Additional funding was provided by the European Research Council (ERC‐CoG 863664) to Paul Wilmes. Kenya Honda was funded through AMED LEAP (JP17gm0010003), and Frederic Zenhausern was funded by NASA (TRISH # NNX16A069A). …”

3

He S, Zhu Y, Tavakol DN, Ye H, Lao YH, Zhu Z, Xu C, Chauhan S, Garty G, Tomer R, Vunjak-Novakovic G, Zou J, Azizi E, Leong KW.

Squidiff: Predicting cellular development and responses to perturbations using a diffusion model .

Nat Methods. 2026 Jan;23(1):65-77.

https://pubmed.ncbi.nlm.nih.gov/41184550

PI: G. Vunjak-Novakovic

Note: This article may be obtained online without charge.

Journal Impact Factor: 32.1

Funding: “…We gratefully acknowledge funding support from the Translational Research Institute for Space Health (TRISH/NASA) (RAD0104 and NNX16A069A to G.V.-N. and K.W.L.).”

4

Kennedy DM, Neto OP, Weinrich M, Abbott R, Keller N, Rao R, Wright T, Dunbar BJ, Diaz-Artiles A.

Neurophysiological effects of partial gravity on bimanual control: A parabolic flight study .

npj Microgravity. 2026 Apr 16. Early access article.

https://doi.org/10.1038/s41526-026-00595-z

PI: A. Diaz-Artiles

Note: This article may be obtained online without charge.

Journal Impact Factor: 5.1

Funding: “This work was supported by the NASA Human Research Program, Grant Number: 80NSSC20K1499. …”

5

MacRobbie M, Lordos G, Lordos A, Newman D, Stankovic A.

Evaluating the impact of mission architecture on crew dynamics in space exploration .

npj Microgravity. 2026 Apr 17. Early access article.

https://doi.org/10.1038/s41526-026-00574-4

Note: This article may be obtained online without charge.

Journal Impact Factor: 5.1

Funding: “Duquesne University, Biomedical Engineering departmental funds; NASA Pennsylvania Space Grant Consortium, Grant/Award Number: G2300101; NASA Massachusetts Space Grant Consortium individual travel grant. …”

Physical Science papers deriving from NASA support:

6

Jeon S, Lee JJ, Kaban I, Matson DM.

In situ observation of a transient intermediate state during metastable solidification of a Fe–Cr–Ni alloy .

Acta Materialia. 2026 Apr 15;308:122028.

https://doi.org/10.1016/j.actamat.2026.122028

PI: D.M. Matson

Note: This article may be obtained online without charge.

Journal Impact Factor: 9.3

Funding: “Funding for work at Tufts University was provided by NASA under grants 80NSSC19K0256 and 80NSSC24K1119. Parts of this research were carried out at PETRA III synchrotron source at DESY, a member of the Helmholtz Association.”


Other papers of interest:

1

Kumar R, Waisberg E, Ong J.

Chapter 35 - Advancing surgical autonomy in space: Microgravity-optimized procedures, technologies, and countermeasures for the International Space Station .

In: Waisberg E, Ong J, Lee AG, editors. Fundamentals of Space Medicine and Clinical Technology: Academic Press; 2026. p. 489-505.

https://doi.org/10.1016/B978-0-443-32904-3.00001-7

2

Kumar R, Sporn K, Pasha S, Paladugu P, Waisberg E, Ong J, Tavakkoli A.

Advancements in non-invasive intracranial pressure monitoring for spaceflight-associated neuro-ocular syndrome and their implications for neurological monitoring .

Microgravity Sci Technol. 2026 Feb 26;38(2):15.

https://doi.org/10.1007/s12217-026-10238-3

3

Pham J, van der Werf I, Mack K, Jamieson C.

Spaceflight as a cancer research catalyst .

The Lancet Oncology. 2026 Apr;27(4):415-8.

https://doi.org/10.1016/S1470-2045(26)00135-X

Note: From the abstract: “Based on our 5-year experience with nine missions to the ISS and the pioneering research by other groups, we highlight how space research is a catalyst for deciphering the roles of stem-cell pathways and ageing in cancer evolution, as well as for informing the development of novel cancer therapeutics that prevent malignant regeneration, clonal evolution, and immune cloaking by cancer stem cells.”

4

Shpakov AV, Voronov AV.

Influence of long-term space flights on biomechanical characteristics of human walking and the dynamics of their post-flight recovery.

Hum Physiol. 2026 Apr 1;51(6):656-69.

https://doi.org/10.1134/S0362119725700872

Note: ISS results.

5

Padilha CS, Figueiredo C, Deminice R, Ribeiro AS, Newton RU, Hart NH, Rosa-Neto JC, Seelaender M, Lira FS.

Disuse-induced muscle atrophy and muscle weakness from hospitalization to spaceflight: Exercise succeeds in prevention and treatment-A meta-analysis .

J Cachexia Sarcopenia Muscle. 2026 Apr 15;17(2):e70259. Review.

https://pubmed.ncbi.nlm.nih.gov/41983453

Note: This article may be obtained online without charge.

6

Smirnov NN.

Fundamental problems of safety in aerospace flights .

Acta Astronaut. 2026 Aug;245:343-50.

https://doi.org/10.1016/j.actaastro.2026.02.052

7

Yin Y, Wu X, Liu J, Xu C, Zhu Y, Zeng D, Ju T, Duan F, Li Y, Lu W.

Sc-RNA seq reveals the protective effects of Baoyuan Jieyu Formula on spaceflight depression rats .

Space Sci Technol. 2026 Mar 26;6:0321.

https://spj.science.org/doi/abs/10.34133/space.0321

Note: From the abstract: “Long-term spaceflight composite stress (LSCS) can induce detrimental impacts on the human central nervous system, leading to conditions such as depression. This study aimed to identify mechanisms of simulated LSCS-induced spaceflight depression and the protective effects of traditional Chinese medicine Baoyuan Jieyu Formula (BYJYF) on spaceflight depression rats.”

8

Waisberg E, Kumar R, Ong J.

Chapter 17 - Physiological similarities between dive and space medicine .

In: Waisberg E, Ong J, Lee AG, eds. Fundamentals of Space Medicine and Clinical Technology: Academic Press, 2026. p. 285-8.

https://doi.org/10.1016/B978-0-443-32904-3.00023-6

9

Yadav DK, Siby S, Wadikar DD.

Cultivation and synthesis of food for humans beyond Earth: A future view .

Life Sci Space Res. 2026 Apr 9. Review. Online ahead of print.

https://doi.org/10.1016/j.lssr.2026.04.004

10

Li N, Liu L, Wang D, Wang J, Tie Y, Li X, Li J, Gao Y, Yang C, Wang Y.

Mechanisms of mechanical stress-induced vascular remodeling via the Lactate-PKM2 axis and implications for microgravity adaptation.

Int J Mol Sci. 2026 Apr 5;27(7):3298.

https://pubmed.ncbi.nlm.nih.gov/41977476

Note: This article is part of Special Issue “Microgravity, Cell Shape and Gene Expression: State of the Art, Challenges and Prospects” (https://www.mdpi.com/journal/ijms/special_issues/2C75Y41K9S). The Special Issue also includes an article from previous Current Awareness List #1,183 https://doi.org/10.3390/ijms27010341. This article may be obtained online without charge.

11

Bauser HC, Smith PA, Parent SD, Chan LR, Bhavsar AS, Condon KH, McCalip A, Croom JM, Purcell DK, Bogdanowich-Knipp SJ, Smith DT, Cowans BA, Alajlouni R, Byrn SR, Radocea A.

A study on the stability of ritonavir form III processed in orbit and returned to Earth .

npj Microgravity. 2026 Apr 8. Early access article.

https://pubmed.ncbi.nlm.nih.gov/41951637

Note: From the abstract: “Despite notable progress in realizing the benefits of microgravity, the physical stability of therapeutics processed in space has not been sufficiently investigated. Environmental factors including vibration, acceleration, radiation, and temperature, if not addressed, could impact the feasibility of in-space drug processing. The presented work demonstrates the successful recovery of the metastable Form III of ritonavir generated in orbit.” This article may be obtained online without charge.

12

Popova OV, Fedchuk MV, Yakhya YD, Rusanov VB.

Mechanisms of autonomic balance in the human cardiovascular system when a short radius centrifuge is used as a prophylactic means of adverse effects of microgravity.

Hum Physiol. 2026 Apr 1;51(6):670-9.

https://doi.org/10.1134/S0362119725700884

Note: Head-down tilt bedrest study.

13

Asnaghi R, Dias Rodrigues G, Carandina A, Tobaldini E, Montano N, Ferrario M.

A network analysis to identify possible alterations among different physiological systems induced by head-down tilt bedrest.

Appl Netw Sci. 2026 Mar 9;11(1):24.

https://doi.org/10.1007/s41109-026-00773-8

Note: This article may be obtained online without charge.

14

Ranade AV, Bernhardt GV, Jose J, Ramachandran G, Ebby S, Karim A, Ahmad F, Qaisar R, Gowda KMD.

4-Phenylbutyrate mitigates renal pathology linked to ER stress related pathways in C57BL/6J mice with hindlimb unloading .

Sci Rep. 2026 Apr 7;16:11724.

https://pubmed.ncbi.nlm.nih.gov/41946794

Note: This article may be obtained online without charge.

15

Ranade AV, Gul MT, Jose J, Ramachandran G, Karim A, Ahmad F, Bernhardt GV, Qaisar R, Ray A, Km DG.

Mesenchymal stem cell transplantation as a therapeutic strategy to preserve testicular integrity and counteract microgravity-induced male infertility .

Arch Med Res. 2026 Jul;57(5):103414.

https://doi.org/10.1016/j.arcmed.2026.103414

Note: From the abstract: “Prolonged immobility and exposure to microgravity during spaceflight negatively affect male reproductive organs. Various interventional strategies have been employed to mitigate testicular pathology in immobile and/or physically inactive men. However, an effective therapy remains elusive. The experimental rodent model of simulated microgravity (SM), is widely used to study the pathogenesis of male infertility during prolonged bed rest and spaceflight.”

16

Gulimova V, Krivonosov Y, Bukreeva I, Buzmakov A, Junemann O, Asadchikov V, Saveliev S.

Effect of fixative solutions in long-term bone preservation .

Biology (Basel). 2026 Apr 1;15(7):567.

https://pubmed.ncbi.nlm.nih.gov/41972570

Note: This article may be obtained online without charge.

17

Lizard G, Sassi K, Mackrill JJ, Ghzaiel I, Meziane S, Hassen E, Abdelkarim M, Masmoudi-Kouki O, Ghrairi T, Brahmi F, Gargouri A, Rezig L, Benkalifa R, Khallouki F, El Midaoui A, Pincemail J, Atanasov AG, Vejux A, Millot N.

7-ketocholesterol as a theranostic target: Potential applications and future perspectives .

Chem Phys Lipids. 2026 Apr 3:105588. Review.

https://pubmed.ncbi.nlm.nih.gov/41936993

Note: This article may be obtained online without charge.

18

Sha Z, Yang K, Fu S, Tong X, Yang H, Fang H, He Q, Li N, Shu X, Liu Q, Fu B, Liu J, Li Q, Zeng H, Zhang X, Yao R, Zhang X, Guo W, Mao X, Long M, Lin X, Zou Q, Wu H.

Dysregulation of macrophage lipid metabolism underlies intracellular bacterial neuroinvasion .

Nat Commun. 2026 Apr 14. Early access article.

https://pubmed.ncbi.nlm.nih.gov/41980980

Note: This article may be obtained online without charge.

19

Shi Q, Huang Y, Arnas D, DeLaurentis D.

A system-of-systems approach to US space sustainability governance .

Acta Astronaut. 2026 Apr 16. Online ahead of print.

https://doi.org/10.1016/j.actaastro.2026.04.026

Note: From the abstract: “The rapid expansion of satellite deployments and commercial activity in low Earth orbit has outpaced existing policy frameworks, raising urgent concerns about long-term space sustainability. This work proposes and applies a system-of-systems–based framework to assess structural and operational gaps in the United States’ approach to orbital stewardship.”