AI/ML Subgroup for Genetic Perturbation Predictive Modeling (GPPM)

AWG Projects AIML AWG Open Projects
, , , ,
41

Thank you Lauren, will look into them!

1 Like
42

@liamfj17 just came across this paper published last week - Pertpy: an end-to-end framework for perturbation analysis | Nature Methods

2 Likes
43

I love pertpy! I wrote some pipelines that incorporate it. It’s super flexible for all kinds of things – CRISPR, experimental conditions, Perturb-seq, etc.

1 Like
44

Members of this subgroup might appreciate this: Engine | Discover Gene Insights Today — PerturbAI
Full mode: perturbai/wholebrain_crispr_atlas · Datasets at Hugging Face
Preprint: https://www.biorxiv.org/content/10.64898/2026.03.16.711480v1

3 Likes
45

This could be a useful paper on what types of representations work for encoding perturb seq responses and why current models struggle: What Makes a Representation Good for Single-Cell Perturbation Prediction?

1 Like