Digital Twin to Model the Effect of Spaceflight on the Retina

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Hi @jgong, That sounds great! I will have my findings summarized ready for a timely presentation by Friday. However, I most likely will not be able to present during the meeting as I will have major background noise. I will structure the presentation in an easily interpretable manner, so if @amey-agarwal or another member would like to take over, they can do so. I apologzie for the inconvenience, thank you for understanding.

Thanks,
Kush

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Hi @jgong and all, as we discussed in yesterday’s meeting, I have attached the script I used for deconvolution analysis of the bulk RNA-seq data: cibersortx_input_prep.R - Google Drive This script includes both R and Python components for preparing the input for CIBERSORTx. I have also added details on how to run the analysis on CIBERSORTx and how to interpret the results in this presentation: Loading Google Slides Please let me know if you have any questions.

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Hi Lauren,
I was finally able to get the imputation incorporated for flight and non-flight data. Attached is the html (need to download and open in chrome): rr9_retina_dataset.html - Google Drive

There are four imputers I tried, and it looks like MICE with bagging regressor might be a better option to go with.
I am working on setting up the classifier for pre and post imputation to evaluate the imputers.

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Hi all -

I am traveling on the road today but I will try to host a reduced, short meeting, just to check in and go over things. If I come in a little late, it is probably because of the network, but the Zoom will work. Feel free to use this time to discuss amongst yourselves before I come in.

Jian.

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Hi, in this presentation I’ve summarized the analyses I have completed so far: Analysis of RR9 and aging RNA-seq datasets.pptx - Google Slides Unfortunately, I won’t be able to attend today’s meeting, but I will present the updated results next week. Please let me know if you have any questions or suggestions.

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Thanks for an amazing meeting everyone! I had a great time brainstorming.

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Hi @jgong! Could you add me to the email list. Would be interested in getting involved!

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