The Jain Lab (https://ishajainlab.com) at UCSF/Gladstone is looking for motivated, hard-working and curious applicants. At a high level, we study how organisms interact with their environments – how “what we breathe” and “what we eat” affects our metabolism and disease progression. More specifically, we are focused on oxygen and vitamin/cofactor metabolism. We recently discovered that chronic hypoxia (equivalent to living in the mountains of Peru or Nepal) can serve as a therapy for mitochondrial disease. This approach is currently in clinical trials. This work has inspired a broader set of research directions ranging from fundamental biochemistry to animal physiology.
The questions we ask:
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How do cells and organisms sense oxygen or vitamin levels? Are there novel oxygen sensors and vitamin sensors to be found?
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How does the body adapt to variations in oxygen levels? Or vitamin levels?
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When the supply and demand of oxygen or vitamins becomes mismatched, how does this contribute to disease?
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Can we “turn the oxygen and vitamin dials” into creative new therapies?
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What is the most practical form of turning these concepts into translatable therapies?
The approach we take: CRISPR screens, metabolomics, classical biochemistry/molecular biology, animal physiology and beyond.
Post-docs will be encouraged to lead independent projects resulting in high impact publications, present at conferences and prepare for long-term careers in academia or industry.
Please email Isha.Jain@gladstone.ucsf.edu for more info or to apply. @MultiOmicsAWG @AnimalAWG