PP AWG Extraction and Denoising Subgroup

AWG Projects PP AWG Open Projects
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We are pleased to announce a new subgroup within the PP AWG @PPawg focusing on nucleic acid extraction from extremely low biomass environments and mitigation of sequencing noise from the generated data. This group is led by @stefan_green, @Stighe, @cdavis, and @Haley_Sapers. Through this group, we hope to accomplish or address the following:

  • Characterization and comparisons of various kit-omes for improved extraction efficiency and minimal contamination of low-biomass samples.
  • Development of quantitative contamination checkpoints within extraction and sequencing processing steps. Specifically, the inclusion of contamination controls and optimized protocols for handling background noise reduction.
  • Establish and centralize quantitative whole-cell reference standards specific to planetary protection.

Meetings will be held on the third Thursday of each month beginning on July 16th, 2026. Please sign up on the Google Form ( PP AWG - Nucleic Acid Extraction Sub-Group Sign-Up ) to be added to the email reminder list, or add the calendar event within the OSDR webpage for the meeting link. If you have any questions, you can reach out to any of the group leads or comment below.

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How to Be Involved? Master table of Open Sub-Group Projects
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My background is in protein machine learning, bioinformatics, and sequencing data analysis. I’ve recently been working on integrating biological knowledge into protein representation learning and have experience with RNA-seq processing and NASA EDGE sequencing workflows. I’m particularly interested in computational approaches for contamination detection, sequencing quality assessment, and benchmark development. I’d be happy to contribute on the ML or data analysis side if there’s an opportunity.

Here’s my email hitaeshi25sehgal@gmail.com.Looking forward to collaborate!

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