SPACELINE Current Awareness - Publication list August 24, 2026

This is a longstanding listserve of articles relevant to space biology, space health, etc

@AWGall

Everything below is directly from that listserve (I know no more than sharing this useful list):

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at SPACELINE Current Awareness. Please send any correspondence or request to unsubscribe to Shawna Byrd, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.

Papers deriving from NASA support:

1

Kim M, Kremsky I, Pecaut M, Mao XW. @mpecaut @xmao

A ferroptosis-related transcriptional signature in the brain after a 35-day spaceflight.

npj Microgravity. 2026 Aug 13. Early access article.

https://doi.org/10.1038/s41526-026-00649-2

PIs: M. Pecaut, X.W. Mao

Note: ISS results. GeneLab is available at https://genelab.nasa.gov. This article may be obtained online without charge.

Journal Impact Factor: 5.1

Funding: “This work was supported by the NASA Space Biology grant #NNX15AB41G and the open access publication fee was supported by Loma Linda University Basic Sciences. The authors would like to acknowledge research support from the NASA GeneLab for providing access to open-science spatial transcriptomic datasets.”

2

Puukila S, Hoban-Higgins TM, Choi S, Shirazi-Fard Y, Fuller CA, Alberts JR, Ronca AE.

Individual behavior and physiology of group housed mice in a spaceflight habitat.

npj Microgravity. 2026 Aug 15. Early access article.

https://doi.org/10.1038/s41526-026-00638-5

Note: From the abstract: “We designed and performed two ground-based validation studies. First, animals were housed in the Rodent Habitat in groups of five; fur dye markings enabled identification of individual mice. Body temperature was acquired using implanted dataloggers. Video was recorded and species typical behaviors were quantified for individual mice during both light and dark phases. Second, centrifugation was used to mimic launch. For the first time, we validated the biocompatibility of datalogger implants, fur dye pattern application and mouse visual identification methods using digital video and behavioral analysis protocols.” This article may be obtained online without charge.

Journal Impact Factor: 5.1

Funding: “The authors would like to thank the NASA Ames Attending Veterinarian Stephanie Solis and the NASA Ames Animal Care Facility manager Allison Brown for performing dissection and necropsy as well as Steffy Tabares Ruiz for helping perform the fur dying. We’d also like to thank Test Engineer Oscar Roque, Engineering Evaluation Lab manager Chris Rogers and team members Richard Rowan and Brandon Graham, as well as Sustaining Engineering team members Tristan Le, Brian Yu, Chetan Angadi, Tran Burns, and Project Manager of Sustaining Engineering of Rodent Research Ryan Fisher. Finally, we would like to thank Jonathan Galazka, Amy Gresser, Lynn Harrison Clary and Sharmilla Bhattacharya from NASA Space Biology. Funding was provided by the NASA Space Biology Program.”

3

Evans MA, Doviak H, Polizio AH, Cochran JD, Kim LR, Park E, Thel MC, Xie CR, Srinivasan AR, Marino L, Yura Y, Sun H, Mikkilineni S, McKamy AJ, Philippos G, Domingues AF, Vassiliou GS, St Jean SC, Pietras EM, Goukassian DA, Walsh K.

Space radiation promotes clonal hematopoiesis and hematologic disease upon aging in a driver gene and sex-specific manner.

iScience. 2026 Aug 21;29(8):116877.

https://doi.org/10.1016/j.isci.2026.116877

PI: K. Walsh

Note: This article may be obtained online without charge.

Journal Impact Factor: 4.5

Funding: “This work was supported by the United States National Aeronautics and Space Administration grant no. 80NSSC21K0549, the United States Department of Defense grant no. CA210887 and the National Institutes of Health (NIH) grant nos. AG092528, AG073249 and AG086508 to K.W. J.D.C. was supported by the NIH grant no. T32GM007267, Robert R. Wagner Fellowship Fund and iPRIME Student Fellowship. E.M.P. is a Scholar of Blood Cancer United (formerly the Leukemia and Lymphoma Society) and was supported by NIH grant no. DK137183. Flow cytometric data presented in this manuscript were generated in the University of Virginia Flow Cytometry Core Facility (RRID:SCR_017829) and partially supported by the NCI grant no. (P30- CA044579). …”

4

Nakashima K, Farrell C, Calabria J, Millar AH, Massa G, Watt M.

Identifying a new candidate space crop: The alpine strawberry Fragaria vesca.

Life Sci Space Res (Amst). 2026 Sep;52:75-83.

https://pubmed.ncbi.nlm.nih.gov/42601163

Note: This article may be obtained online without charge.

Journal Impact Factor: 3.3

Funding: G. Massa is affiliated with NASA Kennedy Space Center.

__________________________________________________

Other papers of interest:

1

Azargoonjahromi A, Abutalebian F.

Neurobiological effects of microgravity on the human brain: A systematic review of spaceflight and analog studies.

Life Sci Space Res. 2026 Aug 17. Review. Online ahead of print.

https://doi.org/10.1016/j.lssr.2026.08.004

2

Kern C, Woods T, Siew K. @keith.siew

Tackling aging and chronic disease: How space exploration and the “chameleon effect” of pharmaceuticals can lead the way.

Exp Physiol. 2026 Aug 18. Review. Early access article.

https://pubmed.ncbi.nlm.nih.gov/42613889

Note: This article may be obtained online without charge.

3

Fomina EV, Senatorova NA, Romanov PV, Burakova AA, Ivanov DS, Kokueva MA.

Application of countermeasures for hypogravity disorders in a one-year spaceflight for the development of a medical support system for interplanetary missions.

Hum Physiol. 2026 Aug 15;52(2):249-60.

https://doi.org/10.1134/S0362119726700490

Note: From the abstract: “Based on the results of the examination of the cosmonaut during the 1-year spaceflight, it was established that the experimental period with a decrease in the volume of loading along the vertical axis of the body from the 204th to the 216th day of spaceflight was accompanied by a moderate decrease in performance, as evidenced by an increase in the pulse sum of work in response to the performance of a standard locomotor load after this period. …”

4

Gifani M, Burns GW.

The transgenerational toll of maternal spaceflight.

Proc Natl Acad Sci USA. 2026 Aug 25;123(34):e2621879123.

https://pubmed.ncbi.nlm.nih.gov/42607232

Note: This article is a Commentary.

5

Abe C, Fujita SI, Shiba D, Tanaka K, Fujimoto C, Tokunaga S, Iwasaki S, Takahashi S, Muratani M, Morita H. @fumimuratani

Selective saccular plasticity under microgravity links peripheral transcriptomic remodeling to postflight vestibular dysfunction.

Proc Natl Acad Sci USA. 2026 Aug 17;123(35):e2605593123.

https://pubmed.ncbi.nlm.nih.gov/42607193

Note: From the abstract: “Long-duration exposure to microgravity disrupts human balance and spatial orientation, yet the molecular mechanisms underlying vestibular adaptation to spaceflight remain poorly understood. Here, we tested the hypothesis that the saccule, the primary gravity-sensing otolith organ, undergoes selective remodeling during spaceflight and contributes to transient postflight postural instability. Using a cross-species approach, we combined transcriptomic analysis of mouse otolith organs with physiological assessments in astronauts.”

6

Alshehhi S, Taylor C, Jangjoo A, Ibrahim Z, Blaber AP, Al Suwaidi H, Soares NC, El-Hadidi M, Goswami N.

Female transcriptomic responses to simulated microgravity in a dry immersion model: Insights into TP53-regulated stress pathway.

npj Microgravity. 2026 Aug 13. Early access article.

https://doi.org/10.1038/s41526-026-00647-4

Note: This article may be obtained online without charge.

7

Bochimoto H, Kondoh D, Tobe K, Takeda K, Nakayama T, Ishikawa S, Haraguchi T, Shigeishi M, Honjo M, Takizawa R, Kurozumi S, Tatsumi N, Sato Y, Kusakari Y, Okabe M, Muratani M, Minamisawa S. @fumimuratani

Effects of microgravity on gastric glandular histology.

Acta Astronaut. 2026 Aug 18. Online ahead of print.

https://doi.org/10.1016/j.actaastro.2026.08.044

Note: From the abstract: “How the mechanisms and histopathology of the digestive system are altered during spaceflight are not understood in detail. We used the Multiple Artificial-gravity Research System (MARS) in the JAXA platform to compare the effects of μG and cosmic rays on the histopathology of gastric glandular mucosa cells in mice on the ground (1G), μG, and artificial 1 G (A1G) during spaceflight.”

8

Nie P, Liu Y, Zheng Y, Zhang C, Chen Q, Ping H, Liu Y, Chen Y, Shuang F, Li J, Longzhu D, Yi L, Weng T.

Cordycepin protects against simulated microgravity-induced osteogenic impairment involving ferroptosis-related signaling.

Biochem Pharmacol. 2026 Aug 16;253(Pt 2):118365.

https://pubmed.ncbi.nlm.nih.gov/42603620

9

Niu Q, Mu T, Zhang J, Chen Y, Guo Z, Zhu Y, Li L.

Gastrointestinal motility in microgravity: A critical review of multi-level mechanisms and model-dependent effects.

Front Physiol. 2026 Aug 20;17:1930628. Review.

https://doi.org/10.3389/fphys.2026.1930628

Note: This article may be obtained online without charge.

10

Zhou Z, Zhang J, Li L, Wu H, Qu S, Shi L, Yin B, Zhu X, Wang Y, Teng HH.

Beyond extremophiles: Conserved molecular toolkits enable the resilience of human-associated microbes to Martian stressors.

npj Microgravity. 2026 Aug 15. Early access article.

https://doi.org/10.1038/s41526-026-00650-9

Note: From the abstract: “The inevitable introduction of human-associated microbes on Mars poses significant planetary protection risks, yet the survival potential of non-extremophiles under surface conditions remains ill-defined. We evaluated the resilience of three common gut bacteria—Enterococcus faecalis, Serratia liquefaciens, and Escherichia coli—under simulated Martian stressors including low pressure, CO₂-rich atmosphere, and perchlorate exposure, applied individually and in combination.” This article may be obtained online without charge.

11

Falk M.

Effects of different types of ionizing radiation on DNA from the perspective of medicine and planned piloted interplanetary flights.

Cas Lek Cesk. 2026;165(3-4):100-16. Review.

https://pubmed.ncbi.nlm.nih.gov/42601200

12

National Academies of Sciences, Engineering, and Medicine.

Assessing Radiation Exposure, Health Outcomes, and Mitigation Strategies for Flight Crewmembers.

Mulrow DJ, Samet JM, eds. Washington, DC: The National Academies Press, 2026. 232 p.

https://doi.org/10.17226/29261

13

Ye Z, Liu B, Dobynde MI, Guo J, Xu XG.

Assessment of lunar surface radiation risks and uncertainties using a full-chain Monte Carlo framework: From lunar radiation environment to dose.

Life Sci Space Res (Amst). 2026 Sep;52:18-29.

https://pubmed.ncbi.nlm.nih.gov/42601149

Note: This article may be obtained online without charge.

14

Zhang Z, Yuan J, Hong M.

The heavy ion-induced up-regulation of ZIP14 is mediated by the PKC-Nrf2 pathway.

Life Sci Space Res. 2026 Sep;52:185-95.

https://doi.org/10.1016/j.lssr.2026.03.001

15

Wakabayashi K, Soga K, Hoson T.

Stimulation of ethylene production in rice seedlings grown under hypergravity conditions.

Life Sci Space Res (Amst). 2026 Sep;52:31-6.

https://pubmed.ncbi.nlm.nih.gov/42601157

16

Richard C.

Psychological monitoring in isolated, confined, and extreme environments: Promise and challenges of ecological momentary assessment.

Front Physiol. 2026 Aug 13;17:1695483.

https://doi.org/10.3389/fphys.2026.1695483

Note: This article is a perspective and part of Research Topic “Human Behavior in Extreme Conditions: Novel Approaches and Technologies” (https://www.frontiersin.org/research-topics/66898/human-behavior-in-extreme-conditions-novel-approaches-and-technologies). The Research Topic also includes an article from previous Current Awareness List #1,132 https://doi.org/10.3389/frvir.2024.1446796. This article may be obtained online without charge.

17

Seol JE, Hargens A, Han J.

Re-evaluating pharmaceutical stability in space: A biomedical and regulatory science framework for long-duration missions.

Life Sci Space Res (Amst). 2026 Sep;52:45-51. Review.

https://pubmed.ncbi.nlm.nih.gov/42601159

Note: From the abstract: “Pharmaceutical stability is a critical determinant of crew health and mission success in long-duration spaceflight. Current regulatory frameworks governing drug stability are primarily based on terrestrial testing paradigms, including International Council for Harmonisation (ICH) guidelines, which assume controlled environmental conditions. However, spaceflight introduces unique stressors such as microgravity, ionizing radiation, exposure to the vacuum of space, and operational constraints that are not accounted for in existing models. This study systematically evaluates the limitations of current regulatory systems through a structured review of experimental evidence, space agency reports, and regulatory documents.”

18

Liu F, Shen H, Wan Q, Li Y, Zhao G, Liu X, Lin W, Xue J.

Alterations in the hepatic drug-metabolizing enzyme network of mice induced by +Gz exposure and its impact on the pharmacokinetics and pharmacodynamics of modafinil.

Front Pharmacol. 2026 Aug 2;17:1818737.

https://pubmed.ncbi.nlm.nih.gov/42609426

Note: This article may be obtained online without charge.

19

Cui Z, Xie T, Zhou Y, Gong P, Zhang X, Wang P.

Exploring the differences in neural oscillation mechanisms before and after sleep deprivation.

Front Neurosci. 2026 Aug 2;20:1910878.

https://pubmed.ncbi.nlm.nih.gov/42609404

Note: This article may be obtained online without charge.

20

De Martino E, Lyu P, Brahim I, Hameed MS, Arendt-Nielsen L, Hadjiat Y.

Monitoring and modulating interconnected physiological systems in space using portable closed-loop technologies.

Front Netw Physiol. 2026;6:1867627.

https://pubmed.ncbi.nlm.nih.gov/42597500

Note: This article is part of Research Topic “Network Physiology in Space: Exploring Physiological Networks during Space Flight for the Benefit of Life on Earth” (https://www.frontiersin.org/research-topics/75817/network-physiology-in-space-exploring-physiological-networks-during-space-flight-for-the-benefit-of-life-on-earth). The Research Topic includes articles from previous Current Awareness List #1198 https://doi.org/10.3389/fnetp.2026.1817815. This article may be obtained online without charge.

21

Fedchuk M, Nosovsky A, Rusanov V.

Sex differences in regulatory mechanisms of the cardiovascular system during simulated hypokinesia.

Life Sci Space Res. 2026 Sep;52:205-13.

https://doi.org/10.1016/j.lssr.2026.03.003

Note: From the abstract: “The study examined sex-specific differences in the autonomic response to simulated hypokinesia. Nine healthy males (23±3 years) and nine females (26±3 years) underwent 5‑day dry immersion. Heart rate variability (HRV) analysis and factor analysis (8 indices) were used to assess autonomic regulation.”

22

Kim S-M, Kook J-H, Choi J-I, Ogundele OM, Lee W-C, Kim H-T.

Effects of clinostat rotation on stem morphology of Pisum sativum.

Life Sci Space Res. 2026 Aug 14. Online ahead of print.

https://doi.org/10.1016/j.lssr.2026.08.003

Note: A 2D clinostat was used in this study to simulate microgravity.

23

Ma X, Wang D, Wang Y, Wang F, Qu A.

Effects of crew seat inclination on multi-organ injury risk in astronauts during off-nominal high-g landing impact.

Ann Biomed Eng. 2026 Aug 15.

https://pubmed.ncbi.nlm.nih.gov/42603230

24

Masoudi S, Kalani M, Alavianmehr A, Mosleh-Shirazi MA, Mortazavi SMJ, Farjadian S.

Immune cell dysregulation in hindlimb unloading mouse model: Implications for space applications.

J Biomed Phys Eng. 2026 Aug;16(4):343-52.

https://pubmed.ncbi.nlm.nih.gov/42582351

Note: This article may be obtained online without charge.

25

Popa M.

The contribution of Romanian psychologists to Dumitru Prunariu’s spaceflight.

Psihologia Resurselor Umane. 2026 Aug 18;24(1):2-30.

https://www.hrp-journal.com/index.php/pru/article/view/650

Note: This article is an Editorial and may be obtained online without charge.

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