A Unified Mechanistic Model for Trajectory‑Dependent Biological Adaptation

I am sharing a theoretical framework that explains reversible telomere dynamics in microgravity, non‑linear aging plateaus on Earth, and cancer as a predictable exception.

The model treats gravity as an inertial compressional load and is defined as:

ln[S(t)/S₀] = [–α – βΔg] × (1 – e^{-t/τ}) – λR t + ε

This model aligns with NASA Twins Study data and the meta‑analysis by Ye et al. (2023). It predicts:

  • A non‑linear aging plateau
  • Reversible telomere changes in spaceflight
  • Cancer as a hyperactive‑β exception

The model is falsifiable and testable. I am looking for feedback, collaboration, or discussion.

Full preprint: OSF
GitHub: https://github.com/yourusername/trajectory-biological-response-model