Behavior and Neuroinflammation

Hello everyone!

I wanted to share a quick update on the dopamine project.

Over the past few weeks, we’ve had several discussions with collaborators and researchers involved in the RR-1 mission to better understand the available datasets and define the project’s direction. Based on those conversations, we’ve decided to slightly refine our focus.
Our initial plan was to investigate dopaminergic markers. However, after exploring the datasets currently available through OSDR, we decided to broaden our approach. Our current goal is to investigate the relationship between behavior (particularly the circling phenotype observed during the SpaceX-4 mission), neuroinflammation (inflammasome-related pathways), and the spaceflight/radiation environment. We’re also exploring how these findings might eventually connect with available human datasets.
We’ll be starting monthly project meetings very soon to discuss the datasets, plan analyses, review the literature, and coordinate tasks.

If you’re interested in:

  • behavioral neuroscience,
  • neuroinflammation,
  • radiation biology,
  • computational analysis,
  • bioinformatics,
  • or simply learning more about the project,

we’d be very happy to have you join us!
Feel free to reply here or send me a message or an email (claracarrias@gmail.com) if you’d like to participate or receive the meeting invitation.
Looking forward to collaborating with everyone!

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Hi Maria Clara, this seems like a really cool project. I’d love to learn how to get involved!

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Hi Matthew,

Thank you so much! I’m really glad to hear that! We’d be very happy to have you involved!

If you’re interested, could you please send me a direct message here or share your email address? That way I can send you the meeting invitation and keep you updated on future meetings!!

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Thanks for posting the sub-group project @ClaraCarrias

What expertise and inputs from AWG members are you looking for on this project?

Previous reading links, or examples?

Hi Ryan,

Thank you for your question! At this stage, we’re especially looking for people interested in:

  • behavioral neuroscience and behavioral analysis;
  • neuroinflammation and inflammasome biology;
  • radiation biology and spaceflight physiology;
  • bioinformatics and multi-omics data analysis;
  • computational modeling and statistics.

Since we’re still in the early stages, we’re also very interested in relevant papers, review articles, or examples of similar approaches that could help us refine the project.

Some of the key papers guiding our current discussions are:

More broadly, we’re looking for collaborators who enjoy brainstorming ideas and would like to help shape the direction of the project. Different backgrounds and perspectives are always welcome!